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Set up a group for wife in MobileMe. Went to send email to group and  couldn't select it, only could check/ select indivdual addresses. Been  all over Apple/Me.Com help to no avail. Any solutions for the  knowledge challenged ? 
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I'm affraid I may need a little more information.  But I'll assume you mean you set a group up within address book.  Once you've set up a group within address book, all that should be required is to begin typing the group name within the "TO" address field in Apple's Mail.app.  (The stamp) If you are using an application other that Mail, then address book's groupings may not work.  

You could also open address book, select the group then right click (or control+click) to send a bulk email to the group as well.  

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