Hope all is good with you and your family!  I have tried to alt command esc but won't help. What can I do?
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If command+option+esc doesn’t bring up the force quit dialogue box then you’re only option is to hold the power button down to force power off the machine. You’ll lose unsaved documents but hopefully you’ll be back up with no problem.

Not to worry too much...that can also be a sign of a dying hard drive. Ugh.